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  2. November, 9, 2021: U.S. Patent No. U.S. 11,168,064 "Synthesis of thapsigargin, nortrilobolide, and analogs thereof"

November, 9, 2021: U.S. Patent No. U.S. 11,168,064 "Synthesis of thapsigargin, nortrilobolide, and analogs thereof"

Nov 09, 2021

November 9, 2021

ϳԹԴ Partnerships and Innovation is pleased to report the issuance of U.S. Patent No. 11,168,064 entitled, “Synthesis of thapsigargin, nortrilobolide, and analogs thereof,” on November, 9, 2021 to P. Andrew Evans and Dezhi Chen. The invention relates to the preparation of compounds of Formula I, including thapsigargin, nortrilobolide and 8-O-debutanoyl-thapsigargin from commercially available (R)-(-)-carvone via synthetic intermediate compound of formula 12 by pinacol coupling and in situ lactonization.

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